Status:
TERMINATED
Study of Tumor Tissue Samples From Patients With Stage I, Stage II, or Stage III Malignant Melanoma
Lead Sponsor:
Case Comprehensive Cancer Center
Collaborating Sponsors:
National Cancer Institute (NCI)
Conditions:
Melanoma (Skin)
Eligibility:
All Genders
Brief Summary
RATIONALE: Studying the genes expressed in samples of tumor tissue from patients with cancer may help doctors identify biomarkers related to cancer. PURPOSE: This research study is looking at tumor t...
Detailed Description
OBJECTIVES: * Determine the genetic profile of primary melanomas with and without synchronous regional nodal involvement by examining for 1) activating mutations B-Raf and N-Ras associated with melan...
Eligibility Criteria
Inclusion
- Node positive Group (experimental group)
- Primary melanoma \> 2 mm in depth
- Metastasis must be \> 0.1 mm and detectable by IHC or hematoxylin and eosin (H\&E) to be considered node positive
- Slides and block for primary and node must be archived in UH dermatopathology
- Node Negative Group (control group)
- Primary melanoma \> 2 mm in depth
- A negative sentinel lymph node must be negative by IHC and H\&E
- No stage IV disease
- No acral and mucosal histology
- No history of prior invasive melanoma
- Underwent primary excision and sentinel lymph node biopsy within 3 months of each other
- Archived tissue available
- Slides and block for primary tumor and node biopsy must be archived in University Hospitals Case Medical Center (UH) dermatopathology
Exclusion
- Acral and mucosal histology
- Previous diagnosis of invasive melanoma
- previous chemotherapy or immunotherapy
- patients who are found to have stage IV disease during workup
Key Trial Info
Start Date :
July 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 1 2016
Estimated Enrollment :
5 Patients enrolled
Trial Details
Trial ID
NCT00991991
Start Date
July 1 2009
End Date
March 1 2016
Last Update
May 17 2016
Active Locations (1)
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1
Case Medical Center, University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center
Cleveland, Ohio, United States, 44106