Status:
COMPLETED
Cognitive Flexibility in Major Depression in the Course of Pharmacological and Psychotherapeutic Treatment
Lead Sponsor:
Zentrum für Integrative Psychiatrie
Collaborating Sponsors:
German Research Foundation
Conditions:
Cognitive Performance in Major Depression
Eligibility:
All Genders
20-45 years
Phase:
NA
Brief Summary
Cognitive deficits in major depression seem explicable by the well-recognized concept of impaired neuroplasticity in mood disorders. This concept initially emerged from preclinical evidence that antid...
Detailed Description
We randomly assigned forty-five depressive patients to one of three treatment groups (Citalopram, Reboxetin or interpersonal psychotherapy (IPT)). At baseline, day 7 and day 28 we assessed the severit...
Eligibility Criteria
Inclusion
- Diagnosed according DSM-IV criteria as suffering from major depressive disorder
- A baseline score of at least 18 in the Hamilton Depression Scale (HAMD)
- No psychopharmacological treatment at least one week prior inclusion or 3 days wash-out
Exclusion
- Severe depressive episode and/or psychotic depressive episode
- Axis I disorder:
- Substance-related Disorders
- Psychotic Disorders
- Dementia or other cognitive Disorders
- Obsessive-Compulsive Disorders
- Axis II disorder:
- • Borderline Personality Disorder
- Axis III disorder:
- Infectious Diseases
- Cancer
- Endocrinological Diseases
- Hematological Diseases
- Autoimmune Diseases
Key Trial Info
Start Date :
August 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2008
Estimated Enrollment :
45 Patients enrolled
Trial Details
Trial ID
NCT00993876
Start Date
August 1 2005
End Date
August 1 2008
Last Update
October 14 2009
Active Locations (1)
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1
Zentrum für Integrative Psychiatrie
Kiel, Germany, 24105