Status:
COMPLETED
The Incretin Secretion in the Gut System Related to the Physiological Stimulus
Lead Sponsor:
Catholic University of the Sacred Heart
Conditions:
Obesity
Eligibility:
All Genders
30-60 years
Brief Summary
Insulin secretion and insulin sensitivity are related with an inverse, hyperbolic function, the so called disposition index, that shows the critical importance of the ß-cell dysfunction for the develo...
Detailed Description
For intestinal perfusion, a tube assembly (outer diameter 7 mm) marked with a length scale is used. It consists of six tubes that are bonded together with tetrahydrofuran (Sigma Chemical Corp, St Loui...
Eligibility Criteria
Inclusion
- Males and females
- Women in fertile age should engage themselves in avoiding pregnancy during the study protocol. Before starting each experimental session a pregnancy test will be performed and pregnant women excluded from the investigation. All women will be studied in the follicular phase of their menstrual cycle 30 to 60 years old.
- HbA1c between 6.5 and 8.5% (for patients with T2DM only)
- BMI between 30-40 Kg /m2
Exclusion
- Past or active medical history of major endocrinological, renal, cardiac, respiratory, liver or gastro-intestinal diseases.
- All Diabetic patients must have never been treated with oral hypoglycemic agents or insulin.
Key Trial Info
Start Date :
January 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 1 2011
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00994435
Start Date
January 1 2009
End Date
January 1 2011
Last Update
March 24 2011
Active Locations (1)
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1
Department of Metabolic Diseases, Institute of Internal Medicine - Catholic University
Rome, Rome, Italy, 00168