Status:
COMPLETED
Ischemia/Reperfusion Injury of Human Endothelium: Role of Glucose and Statins
Lead Sponsor:
US Department of Veterans Affairs
Conditions:
Hyperglycemia
Eligibility:
All Genders
18-35 years
Phase:
NA
Brief Summary
Anesthetic preconditioning (APC, a brief exposure to an anesthetic gas) has become an area of intense research interest because of its ability to protect tissue and organs from injury resulting from a...
Detailed Description
Injury to vital organs and tissue can occur when blood flow is stopped and then re-established. This happens in a variety of clinical situations and contributes to poor outcomes. A newer concept of pr...
Eligibility Criteria
Inclusion
- Young, healthy volunteers, 18-35 yr of age;
- Females will be studied at the same phase of their estrous cycle in each protocol.
Exclusion
- Beta-blocker therapy or any medication that might interfere with vascular responses;
- Pregnant or lactating women;
- Substance abusers;
- Smokers;
- Anyone with cardiovascular, renal, or other systemic disease including hypertension and/or diabetes;
- Also excluded are volunteers with family history of malignant hyperthermia, or significant gastro-esophageal reflux.
Key Trial Info
Start Date :
March 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2013
Estimated Enrollment :
59 Patients enrolled
Trial Details
Trial ID
NCT00995670
Start Date
March 1 2010
End Date
September 1 2013
Last Update
March 17 2015
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Zablocki VA Medical Center, Milwaukee
Milwaukee, Wisconsin, United States, 53295-1000