Status:
COMPLETED
Chromium's Effect on Insulin Resistance in Obesity
Lead Sponsor:
Stony Brook University
Conditions:
Insulin Resistance
Obesity
Eligibility:
All Genders
18-45 years
Phase:
NA
Brief Summary
This research is to investigate the nutritional supplement chromium picolinate. A large number of people use chromium picolinate from health food stores to improve the function of the hormone insulin....
Eligibility Criteria
Inclusion
- age \> 18 years;
- a BMI greater or equal to 30; AND
- an abnormal 2 hour postprandial glucose (greater than 140 mg/dl but less than 200 mg/dl) following 75 grams of a glucose load.
Exclusion
- positive pregnancy test (all women must have a negative pregnancy test before beginning protocol);
- diagnosis of cancer;
- acute illness of any sort, however, patients may be enrolled once they are stable;
- hemoglobin less than 11.0 g/dl or hemodynamically unstable;
- creatinine greater than or equal to 1.5 mg/dl;
- liver dysfunction as evidenced by elevations in transaminases 2-fold higher than upper limit of normal;
- use of certain medications within the past month (e.g., glucocorticoids).
- untreated hypertension (systolic BP \> 150 mmHG, diastolic BP\>IOO mmHG);
- patients with diabetes mellitus;
- hypogonadism;
- abnormal thyroid function (serum T4 \< 4 or \> 12; TSH \< 0.35 or \> 5.5) (12) any chronic liver or kidney disease; OR
- polycystic ovarian syndrome.
Key Trial Info
Start Date :
April 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2010
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00997659
Start Date
April 1 2007
End Date
May 1 2010
Last Update
August 12 2011
Active Locations (1)
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1
Stony Brook University GCRC
Stony Brook, New York, United States, 11794