Status:
TERMINATED
Lithium in Multiple System Atrophy
Lead Sponsor:
Federico II University
Conditions:
Multiple System Atrophy
Eligibility:
All Genders
18-80 years
Phase:
PHASE2
Brief Summary
The purpose of this study is to determine safety and tolerability of the treatment with lithium in Multiple System Atrophy. Moreover, clinical symptoms, neuronal loss, quality of life and depressive s...
Detailed Description
Patients will be progressively enrolled in the study and undergo a screening visit to test for inclusion/exclusion criteria. Patients will then be randomized to receive either Lithium carbonate or pla...
Eligibility Criteria
Inclusion
- Clinical diagnosis of probable MSA (Gilman, et al. 2008)
- Age ≥18, \<80
Exclusion
- Heart failure
- Liver disease
- Kidney failure
- Thyroid disease
- Sick sinus syndrome and/or significant ECG alterations
- Hyposodemia
- Treatment with diuretics
- Treatment with haloperidol and/or other antipsychotics
- Treatment with NSAIDs or corticosteroids
- Treatment with ACE inhibitors
- Treatment with aminophyllines
- Treatment with mannitol
- Pregnancy and/or breastfeeding
- Acute diseases that might interfere with the trial
Key Trial Info
Start Date :
October 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2011
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT00997672
Start Date
October 1 2009
End Date
August 1 2011
Last Update
February 3 2014
Active Locations (1)
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1
Dipartimento di Scienze Neurologiche
Napoli, Italy, 80131