Status:
COMPLETED
Early Diagnosis of Diastolic Dysfunction and Reliability of DSE in Detecting Stress Diastolic Dysfunction
Lead Sponsor:
University of Missouri-Columbia
Collaborating Sponsors:
Kansas City Veteran Affairs Medical Center
Conditions:
Diastolic Dysfunction
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
The heart becoming "stiff" due to increased fibrous tissue or decreased elasticity of the heart tissue is one of the earliest changes caused by heart failure. These changes can be detected by simple n...
Detailed Description
The heart becoming "stiff" due to increased fibrous tissue or decreased elasticity of the heart tissue is one of the earliest changes caused by heart failure. These changes can be detected by simple n...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Prospectively enroll 25 veterans age range from 18 to 65 who are found to have normal left ventricular (LV) systolic function and no significant coronary artery disease by cardiac catheterization.
- Subjects identified during routine cardiac testing to have significant diastolic dysfunction may also be enrolled to rule out coronary disease and study DSE -invasive pressure correlations.
- Exclusion criteria:
- Patients with LV systolic dysfunction, severe coronary lesions (\> 50%), uncontrolled hypertension (BP \> 160/100) and significant pulmonary hypertension (PASP \> 50 mmHg) would be excluded.
- Subject will not be included if they have a significant rhythm abnormality, frequent premature ventricular complexes, atrial fibrillation and technical reasons in the catheterization laboratory which preclude the study protocol.
Exclusion
Key Trial Info
Start Date :
June 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2011
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT00998205
Start Date
June 1 2008
End Date
January 1 2011
Last Update
April 6 2017
Active Locations (1)
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1
University of Missouri
Columbia, Missouri, United States, 65212