Status:
COMPLETED
Hemodynamics, Salt Sensitivity and Body Composition in Patients With Morbid Obesity
Lead Sponsor:
Zealand University Hospital
Collaborating Sponsors:
Glostrup University Hospital, Copenhagen
Conditions:
Obesity
Hypertension
Eligibility:
All Genders
18-70 years
Brief Summary
The purpose of this study is to evaluate the effect of high vs. low sodium intake on blood pressure and system hemodynamics in patients with morbid obesity and to evaluate the impact of laparoscopic g...
Detailed Description
Overweight and obesity are rapidly increasing in Western countries and are associated with increased mortality and morbidity. The increased morbidity is assumed to be mediated mainly by insulin resist...
Eligibility Criteria
Inclusion
- Inclusion Criteria (cases):
- Caucasians fulfilling the criteria for laparoscopic gastric bypass.
- 12 participants with hypertension, defined as blood pressure \> 140/90 and/or use of antihypertensive medication and 12 participants without hypertension.
- Body mass index 40-50 kg/m2
- Inclusion Criteria (controls):
- Caucasian.
- No hypertension or use of antihypertensive medication.
- Body mass index \< 30 kg/m2
- Exclusion Criteria (all):
- Pregnancy
- Chronic obstructive pulmonary disease
- Diabetes mellitus
- Medical treatment with sibutramine.
Exclusion
Key Trial Info
Start Date :
November 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 1 2013
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT00998465
Start Date
November 1 2009
End Date
January 1 2013
Last Update
March 20 2013
Active Locations (1)
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1
University Hospital Koege, Department of Clinical Physiology and Nuclear Medicine
Koege, Denmark, DK-4600