Status:
COMPLETED
Reflectometric Measurement of Retinal Oxygen Saturation in Patients With Chronic Obstructive Pulmonary Disease (COPD) Grade IV and Healthy Subjects
Lead Sponsor:
Medical University of Vienna
Conditions:
Retinal Artery
Retinal Veins
Eligibility:
All Genders
18+ years
Brief Summary
An adequate oxygenation and retinal perfusion is essential for the function of the inner retina. There is a wide range of autoregulation mechanisms to ensure a sufficient ocular blood and oxygen suppl...
Eligibility Criteria
Inclusion
- Inclusion criteria for healthy subjects:
- Men and women aged between 18 and 99 years
- Tiffeneau Index \> 70 %
- Body mass index between 15th and 85th percentile
- Normal ophthalmic findings, ametropia \< 3 Dpt.
- Inclusion criteria for COPD patients:
- Men and women aged between 18 and 99 years
- COPD grade IV, oxygen dependent and with a forced expiratory volume in 1 second (FEV1) \< 30 %
- Body mass index between 15th and 85th percentile
- Normal ophthalmic findings, ametropia \< 3 Dpt.
Exclusion
- Healthy subjects:
- Regular use of medication, abuse of alcoholic beverages, participation in a clinical trial in the 3 weeks preceding the study
- Treatment in the previous 3 weeks with any drug except oral contraceptives
- Symptoms of a clinically relevant illness in the 3 weeks before the study day
- Blood donation during the previous 3 weeks
- COPD patients:
- Abuse of alcoholic beverages, participation in a clinical trial in the 3 weeks preceding the study
- Health status which does interfere with study procedure or their safety
- Blood donation during the previous 3 weeks
- Symptoms of a clinically relevant illness other than COPD or COPD related in the 3 weeks before the study day
Key Trial Info
Start Date :
November 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 1 2012
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00999024
Start Date
November 1 2009
End Date
October 1 2012
Last Update
February 4 2013
Active Locations (1)
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1
Department of Clinical Pharmacology, Medical University of Vienna
Vienna, Vienna, Austria, 1090