Status:
COMPLETED
Response to Influenza Virus Vaccination in Patients Immunocompromised Due to Chemotherapy
Lead Sponsor:
St. Antonius Hospital
Conditions:
Mamma Carcinoma
Heart Failure
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Patients treated with chemotherapy or immunosuppressives are at higher risk of influenza infection and mortality and morbidity are higher compared to healthy adults. Vaccination against the influenza ...
Detailed Description
This study will be conducted to answer the question whether vaccination during chemotherapy induces an adequate antibody response in oncology patients. Moreover, the effect of the timing of the vaccin...
Eligibility Criteria
Inclusion
- Patients with mamma carcinoma treated with FEC-containing triweekly chemotherapy at moment of vaccination
- Patients with heart failure and therefore having an indication for the influenza vaccination
- Age ≥ 18 years
- Signing of informed consent
Exclusion
- Fever at time of vaccination defined as a temperature of ≥ 38.5 °C.
- Previous/known allergic reaction to any of the components of the vaccines given, for example hypersensitivity to egg protein
- Thrombocytopenia (defined as \< 50 \* 109/L ) at moment of vaccination
- Treatment with prednisolone on moment of vaccination.
Key Trial Info
Start Date :
October 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2009
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT01000246
Start Date
October 1 2009
End Date
December 1 2009
Last Update
December 18 2009
Active Locations (8)
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1
Maxima Medisch Centrum
Eindhoven, North Brabant, Netherlands, 5600 PD
2
Medisch Centrum Alkmaar
Alkmaar, North Holland, Netherlands, 1800 AM
3
Spaarne Ziekenhuis
Hoofddorp, North Holland, Netherlands, 2134 TM
4
Martini Hospital Groningen
Groningen, Provincie Groningen, Netherlands, 9700 RM