Status:
COMPLETED
Effect of Prednisone onTregs and TH17
Lead Sponsor:
University of Chicago
Conditions:
Chronic Rhinosinusitis
Eligibility:
All Genders
18-45 years
Brief Summary
The primary objective of this study is to see whether systemic corticosteroids (such as Prednisone) have an effect on the peripheral blood Treg and Th17 function in patients with CRS. Patients are tak...
Eligibility Criteria
Inclusion
- Diagnosis of CRS.
- A CT scan performed in the last year depicting the severity of the disease or nasal polyps on endoscopy.
- Symptomatic at the time of entry into the study as determined by scores ≥ 1.4 on the Rhinosinusitis disability index
Exclusion
- Women who are pregnant or breastfeeding.
- Patients with severe medical condition(s) that in the view of the investigator prohibits participation in the study (heart, lung, kidney, diabetes, osteoporosis, cataracts, glaucoma, neurological, oncologic, liver disease or a contraindication to taking prednisone).
- Use of any other investigational agent in the last 30 days.
- Use of clinical drugs like antihistamines, leukotriene modifiers, intranasal steroids, systemic corticosteroids in the last 15 days or immunotherapy in the last year.
- Upper respiratory infection within 14 days of study start
- Smoking within the last 2 months.
Key Trial Info
Start Date :
November 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2010
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT01002313
Start Date
November 1 2009
End Date
December 1 2010
Last Update
March 27 2014
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
The University of Chicago
Chicago, Illinois, United States, 60637