Status:
COMPLETED
Visual Selective Attention in Parkinson's Disease
Lead Sponsor:
University Hospital, Grenoble
Conditions:
Visual Attention in Parkinson's Disease
Eligibility:
All Genders
21+ years
Brief Summary
Parkinson's disease (PD), which is generally considered to be a motor disorder, is now known to be accompanied in many instances by a variety of cognitive defects. This can be explained considering th...
Detailed Description
Study Model: parallel-groups study. Three groups of subjects will be enrolled for the study: 2 groups of PD patients (see for details the section groups/cohorts), and a group of healthy controls.
Eligibility Criteria
Inclusion
- PD patients and healthy controls will be matched for age, sex, and education. PD patients: group #1 e group #2
- Idiopathic Parkinson's Disease at a disease's stage characterized by motor complications
- Able to tolerate a prolonged condition without medication
- Levodopa response \> 30% (for group #1)
- Self-declared normal or corrected to normal vision
- At least one contact lead in the sensorimotor part and another contact in the associativelimbic part of the STN (for group #2).
- Patients with a healthy social security affiliation
- Able to give and sign the informed consent
Exclusion
- Patients under guardianship, interdicted, or under administrative measures and legal constraints
- Fertile women not using adequate contraceptive methods
- Women who are pregnant or breast feeding
- Severe cognitive impairment
- Severe frontal executive functions impairment
- Actual psychotic disorders
- Major depression
- Motivation impairment
- Any medical or psychological problems which may interfere with a smooth conduction of the study protocol
- Significant deficiency in red-green color discrimination
- Drug or alcohol addiction
- Healthy controls: group #3
- Inclusion Criteria:
- Self-declared neurologically healthy subjects,
- Self-declared normal or corrected to normal vision
- No psychotropic or neurotrophic drugs intake
- Subjects with a healthy social security affiliation
- Able to give and sign the informed consent
Key Trial Info
Start Date :
October 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 1 2010
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT01135407
Start Date
October 1 2009
End Date
July 1 2010
Last Update
November 22 2010
Active Locations (1)
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1
Unité des Troubles du Mouvement, Clinique de Neurologie, Grenoble University Hospital
Grenoble, France, 38043