Status:
COMPLETED
Detecting Heart Disease Using First Pass Imaging With Gated SPECT Perfusion
Lead Sponsor:
Yale University
Collaborating Sponsors:
Astellas Pharma US, Inc.
Conditions:
Ischemic Heart Disease
Eligibility:
All Genders
18-80 years
Brief Summary
The aim of this study is to determine if stress first pass imaging in conjunction with a nuclear scan will improve the sensitivity for detecting heart disease. This study will also test the usefulness...
Detailed Description
In this clinical trial, patients with suspected or previously diagnosed coronary artery disease who are clinically referred for either a treadmill exercise stress/rest SPECT study or a vasodilatation ...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Males and females age 18 through 80 years
- Female patients who are: surgically sterile (hysterectomy or bilateral tubule libation), at least one year post-menopausal, or have a negative pregnancy test on the day of treatment
- Written informed consent
- Exclusion Criteria:
- Patient consumed food/beverage/medication containing caffeine/methylxanthines up to 12 hours prior to infusion
- Exacerbation of COPD, Asthma (actively wheezing)
- Sinus node dysfunction in absence of pacemaker
- Use of Aggrenox (ASA/Dipyridamole), Pentoxifylline (Trental) , or oral Dipyridamole (Persantine)
- Atrial fibrillation
- Pregnant/breast feeding
- Non English speaking patients
- Subject is allergic or intolerant to aminophylline, regadenoson
- Subject has a history of known or suspected bronchospastic lung disease \[e.g., asthma, wheezing, chronic obstructive pulmonary disease (COPD, etc.)\]
- Patients with first degree or second degree AV block
Exclusion
Key Trial Info
Start Date :
August 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT01137409
Start Date
August 1 2010
Last Update
May 20 2015
Active Locations (1)
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1
Yale New Haven Hospital
New Haven, Connecticut, United States, 06510