Status:
COMPLETED
Halifax Treatment Refractory Depression Trial
Lead Sponsor:
Joel Town
Collaborating Sponsors:
Nova Scotia Health Authority
Conditions:
Depression
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
This study will use a randomized parallel group design to examine the effects of Intensive Short-term Dynamic Psychotherapy (ISTDP) for depressed patients non-remitting following at least one course o...
Detailed Description
Major depression is a common morbid condition resulting in chronicity, recurrent disability, loss of physical health, and in many cases, death through suicide or medical conditions. By 2020, depressio...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Patients aged 18 - 65 years.
- Patients must identify depression as their primary problem (rather than being secondary to other mental health diagnosis).
- Any DSM-IV diagnosis of Major Depression as assessed by the Mini Neuropsychiatric Interview plus (M.I.N.I. plus) at time of research intake interview.
- Patients will have had at least one treatment trial of antidepressants at an acceptable therapeutic dose (length ≥ 6 weeks) for the current depressive episode without adequate response (score on the Hamilton Rating Scale for Depression ≥ 16 ) at time of screening interview.
- Patients will not have started new medications in the previous ≥ 6 weeks, or have received psychotherapy treatment in the 12 months prior to being invited to participate in the study.
- Participants will agree to video-taped sessions and will consent to the investigator accessing their information in clinical files and hospital database (e.g., medications, number of visits to health care professionals).
- Exclusion criteria
- Psychotic depression, bipolar depression, substance dependence, severe cluster A or B personality disorders, active suicidality, or cognitive impairment: such that patients require an intervention other than psychotherapy (as per the current protocol for the experimental treatment arm) or patients unable to give consent to treatment.
- Patients with depression due to a general medical condition or secondary to a comorbid mental health or psychosocial condition will be excluded.
Exclusion
Key Trial Info
Start Date :
September 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2017
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT01141426
Start Date
September 1 2012
End Date
October 1 2017
Last Update
August 16 2022
Active Locations (1)
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1
Capital District Health Authority
Halifax, Nova Scotia, Canada, B3H 2E2