Status:
COMPLETED
Polymorphism of Oxidative Stress Genes in the Pathogenesis and Antioxidant Prevention of Contrast Induced Nephropathy
Lead Sponsor:
Huashan Hospital
Conditions:
Nephropathy
Oxidative Stress
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
With the wide use of contrast agents in clinical diagnosis and treatment, contrast induced nephropathy(CIN) accounts for 1/3 of hospital acquired acute renal failure.The mortality rate of patients wit...
Detailed Description
With the wide use of contrast agents in clinical diagnosis and treatment, contrast induced nephropathy(CIN) accounts for 1/3 of hospital acquired acute renal failure,leading to prolonged hospital stay...
Eligibility Criteria
Inclusion
- receiving cardiovascular angiography;
- age 18 to 80 years ;
- signed informed consent.
Exclusion
- baseline serum creatinine level \> 8 mg / dL (707 μmol / L);
- an increase in serum creatinine of 0.5 mg / dL (44.2 μmol / L) or more in the 24 hours before angiography;
- dialysis;
- multiple myeloma;
- pulmonary edema;
- uncontrolled hypertension;
- emergency cardiac catheterization;
- exposure to radiographic contrast media within the preceding 2 days;
- allergy to radiographic contrast media; pregnancy and breast-feeding women; acceptance of mannitol and other anti-oxidant treatment.
Key Trial Info
Start Date :
March 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2011
Estimated Enrollment :
1000 Patients enrolled
Trial Details
Trial ID
NCT01142024
Start Date
March 1 2010
End Date
March 1 2011
Last Update
June 27 2011
Active Locations (1)
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1
Department of cardiology and nephrology,Huashan Hospital
Shanghai, Shanghai Municipality, China, 200040