Status:
COMPLETED
Role of Donor Genetics and Recipient Genetics in Kidney Transplant Outcomes
Lead Sponsor:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Conditions:
Kidney Disease
Kidney Transplantation
Eligibility:
All Genders
18-99 years
Brief Summary
Background: \- Genetic variation in a particular chromosome is a major contributor to the increased risk for kidney disease that is common in people of African descent, although the specific gene, mu...
Detailed Description
Genetic variation in the region of MYH9 and APOL1, located on chromosome 22, is a major contributor to the increased risk for kidney disease that characterizes African descent populations, although th...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- We will study 300 African American kidney transplant dyads.
- INCLUSION CRITERIA FOR DYADS:
- African descent donor and African descent recipient
- Kidney transplant performed Jan 1995 - Dec 2006.
- First kidney transplant
- Kidney only transplant (excluding transplant of any other organ at any other time).
- EXCLUSION CRITERIA:
- We will exclude donors whose kidneys were used in transplants in which two organs were transplanted, e.g. pancreas and kidney, either simultaneously or at separate times. We will exclude donors whose kidneys were used in second or subsequent transplants. Rationale: dual organ transplants and serial transplants are more complicated clinical situations and renal allograft survival may be shorter and thus not comparable with other kidney transplants.
- We will exclude recipients who had HIV, hepatitis B or hepatitis C infection diagnosed either before or after the kidney transplant.
- Children
- Pregnant women will be excluded but invited to participate after delivery. The rationale is the renal function is altered during pregnancy
Exclusion
Key Trial Info
Start Date :
August 12 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 19 2015
Estimated Enrollment :
26 Patients enrolled
Trial Details
Trial ID
NCT01143532
Start Date
August 12 2010
End Date
October 19 2015
Last Update
February 24 2023
Active Locations (1)
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1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892