Status:
COMPLETED
Effects of Remote Ischemic Preconditioning and Postconditioning on Lung Injury During Cardiopulmonary Bypass
Lead Sponsor:
Seoul National University Hospital
Conditions:
Acute Lung Injury
Eligibility:
All Genders
20-80 years
Phase:
NA
Brief Summary
Remote Ischemic Preconditioning(RIPC) and remote ischemic postconditioning(RIPoC) seems to have a protective effect during ischemic period. Using cardiopulmonary bypass(CPB) during open heart surgery ...
Detailed Description
Cardiopulmonary bypass(CPB) can cause lung function deterioration through various mechanisms. Lung parenchymal tissue ischemia resulted by pulmonary atelectasis and decreased bronchial circulation dur...
Eligibility Criteria
Inclusion
- those who aged 18-80 years old and planned to undergo elective open heart surgery using cardiopulmonary bypass
Exclusion
- emergent operation
- preoperative use of inotropics or mechanical assist device,
- left ventricular ejection fraction less than 30%,
- severe liver, renal disease,
- recent myocardial infarction (within 7 days),
- recent systemic infection or sepsis (within 7 days)
- peripheral vascular disease affecting upper limbs
- amputation of the upper limbs
- major combined operation such as aortic surgery or carotid endarterectomy
- descending thoracic aortic surgery
- rare surgeries; cardiac transplantation, correction of complicated congenital anomalies, pulmonary thromboembolectomy, etc
- significantly decreased pulmonary function before the planned surgery (e.g. using ventilator, oxygen therapy, tachypnea, orthopnea, active lung lesion on chest X-ray, FEV1/FVC less than 50% of predicted level, PaO2 less than 80 mmHg)
- intracardiac shunt
- severe pulmonary artery hypertension
- systemic or local steroid therapy
Key Trial Info
Start Date :
May 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 1 2010
Estimated Enrollment :
76 Patients enrolled
Trial Details
Trial ID
NCT01144585
Start Date
May 1 2010
End Date
November 1 2010
Last Update
June 4 2014
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Seoul National University Hospital
Seoul, South Korea