Status:
UNKNOWN
NOMOTHETICOS: Nonlinear Modelling of Thyroid Hormones' Effect on Thyrotropin Incretion in Confirmed Open-loop Situation
Lead Sponsor:
Ruhr University of Bochum
Conditions:
Hypothyroidism
Hyperthyroidism
Eligibility:
All Genders
14+ years
Brief Summary
The NOMOTHETICOS study is a unicentric cross-sectional study for a quantitative analysis of feedback-inhibition in the thyrotropic homeostatic control. Structural parameters are obtained in vivo from ...
Detailed Description
Control of thyroid hormone homeostasis is essential for function and development of the organism and hence for individual health. It is therefore not surprising that the thyroid's function is controll...
Eligibility Criteria
Inclusion
- Outpatients with disconnected feedback control due to the following conditions:
- Overt primary hypothyroidism with TSH level higher than 10 mU/l and FT4 concentration below 7 pmol/L (5.4 ng/L) (Partition 1)
- Overt primary hyperthyroidism with TSH level below 0.1 mU/l and FT4 concentration higher than 18 pmol/L (14 ng/L) (Partition 3)
- All other constellations, if the patient receives substitution therapy with more 1.75 µg Levothyroxin per kg of body mass (Partition 2).
- System in equilibrium (e.g. unchanged substitution dose over the past six weeks)
Exclusion
- Pituitary or hypothalamic dysfunction
- Severe illness that may be associated with euthyroid sick syndrome (non-thyroidal illness syndrome)
- Medication influencing pituitary function
- Pregnancy
- Missing consent for participation in the study
Key Trial Info
Start Date :
June 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 31 2021
Estimated Enrollment :
138 Patients enrolled
Trial Details
Trial ID
NCT01145040
Start Date
June 1 2010
End Date
January 31 2021
Last Update
October 8 2020
Active Locations (3)
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1
Klinikum Ludwigsburg-Bietigheim
Bietigheim, Baden-Wurttemberg, Germany, D-74321
2
Institute for diagnostical radiology, interventional radiology and nuclear medicine, Bergmannsheil University Hospitals, Ruhr University of Bochum
Bochum, North Rhine-Westphalia, Germany, D-44789
3
Medical Hospital I, Bergmannsheil University Hospitals, Ruhr University of Bochum
Bochum, North Rhine-Westphalia, Germany, D-44789