Status:
COMPLETED
Mechanisms of Insulin Facilitation of Memory
Lead Sponsor:
University of Texas at Austin
Conditions:
Memory Disorders
Eligibility:
All Genders
21+ years
Phase:
NA
Brief Summary
The study described in the present application will test the hypothesis that insulin mediated facilitation of memory in Alzheimer's disease (AD) is achieved through enhanced glutamatergic neurotransmi...
Detailed Description
The specific aims of this project will be accomplished through a cross sectional repeated measures design in which 15 participants with mild AD or amnestic MCI will undergo assessments of brain struct...
Eligibility Criteria
Inclusion
- Clinical diagnosis of probable AD
- Age over 21
- Clinical Dementia Rating of 0.5 or 1.0
- Mini Mental State Exam Score\>15
Exclusion
- preexisting diabetes
- significant neurological disease that might affect cognition, other than AD, including stroke, Parkinson's disease, multiple sclerosis
- severe head injury with loss of consciousness \> 30 minutes or with permanent neurological sequelae
- significant medical illness or organ failure, such as uncontrolled hypertension or cardiovascular disease, chronic obstructive pulmonary disease, liver disease, or kidney disease
- current use of anti-psychotic or anti-convulsant medications
- current or previous use of hypoglycemic agents or insulin
- MRI contraindications
- claustrophobia
- pregnancy
Key Trial Info
Start Date :
July 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2014
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT01145482
Start Date
July 1 2010
End Date
April 1 2014
Last Update
November 3 2014
Active Locations (1)
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1
University of texas at Austin
Austin, Texas, United States, 78712