Status:
COMPLETED
Platelet Inhibition and Transcranial Doppler (TCD)-Detected Microemboli During and After Carotid Artery Stenting (CAS) in Asymptomatic Patients Prior to Cardiac Surgery
Lead Sponsor:
R&D Cardiologie
Conditions:
Carotid Stenosis
Eligibility:
All Genders
18-90 years
Phase:
PHASE4
Brief Summary
As with coronary artery stenting, activation and embolisation of platelets occurs with carotid artery stenting (CAS). Based on promising data on the use of clopidogrel plus aspirin in coronary stentin...
Detailed Description
Carotid angioplasty with stent placement (CAS) has become a well-accepted treatment option for carotid artery stenosis. In combination with experience in CAS procedures and the introduction of protect...
Eligibility Criteria
Inclusion
- patient \> 18 years of age
- patient accepted for CAS
- temporal window for TCD available
Exclusion
- severe renal impairment (creatinine\> 1.5mg/dl), abnormal liver function, malignancy, febrile disorder, acute or chronic inflammatory disease and other diseases influencing platelet reactivity
- extreme tortuositas or calcification of the lesion
- inadequate arterial access
- contraindication for angiography
- patient already receiving clopidogrel
- contra-indication to study drugs
- patients with active bleeding or at high-risk of bleeding
- uncontrolled hypertension ( \> 180/110 mmHg) despite optimal medication
- pregnancy and women with inadequate anticonception
Key Trial Info
Start Date :
March 1 2008
Trial Type :
INTERVENTIONAL
End Date :
April 1 2010
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT01146301
Start Date
March 1 2008
End Date
April 1 2010
Last Update
June 22 2010
Active Locations (1)
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1
St-Antonius Ziekenhuis
Nieuwegein, Utrecht, Netherlands, 3435CM