Status:
COMPLETED
Pharmacological Treatment In Osteoarthritis
Lead Sponsor:
Maasstad Hospital
Conditions:
Osteoarthritis
Eligibility:
All Genders
40+ years
Phase:
PHASE3
Brief Summary
The purpose of this study is to determine the efficacy of hydroxychloroquine in hand osteoarthritis.
Detailed Description
Osteoarthritis is the most common joint disease, most frequently involving the hands, resulting in pain, stiffness and loss of hand function. At present, there is no option to prevent the onset or the...
Eligibility Criteria
Inclusion
- Age ≥ 40 years
- Primary hand OA according to the ACR classification
- Heberden or Bouchard nodule or Kellgren-Lawrence grade 1, 2 or 3 changes in ≥ 2 symptomatic joints
- Pain in the dominant hand ≥ 12 months
- Use of an NSAID for ≥ 1 episode of pain
- Written informed consent
Exclusion
- Secondary hand OA, e.g. haemochromatoses, rheumatoid arthritis, posttraumatic
- Kellgren-Lawrence grade 4 OA
- Use of hydroxychloroquine within 3 months before entering the study
- Use of NSAIDs or corticosteroids within 7 days before entering the study
- Retinopathy
- Myasthenia gravis
- Known allergy or hypersensitivity for hydroxychloroquine
Key Trial Info
Start Date :
July 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2014
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT01148043
Start Date
July 1 2010
End Date
September 1 2014
Last Update
April 13 2015
Active Locations (6)
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1
Admiraal de Ruyter Hospital
Goes, Netherlands
2
Maasstad Hospital
Rotterdam, Netherlands, 3079DZ
3
Erasmus Medical Center
Rotterdam, Netherlands
4
Sint Franciscus Gasthuis
Rotterdam, Netherlands