Status:
COMPLETED
Oxidative Stress in Chronic Kidney Disease: Diet and Exercise
Lead Sponsor:
Vanderbilt University
Collaborating Sponsors:
University of Washington
Conditions:
Chronic Kidney Disease
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
The central aim of this study is to improve understanding of how metabolic pathways that contribute to adiposity also amplify risks of kidney disease progression and cardiovascular disease in subjects...
Eligibility Criteria
Inclusion
- Stage III-IV CKD measured by the MDRD equation with eGFR 15-60 ml/min/1.73m2;
- Age 18-75 years;
- BMI ≥ 25;
- Life expectancy ≥ 1 year;
- Ability to understand and provide informed consent.
Exclusion
- Any acute inflammatory condition (including chronic infection requiring treatment, and collagen vascular disease including active gout);
- Pregnancy;
- Taking high-dose anti-oxidants (Vitamin E or C);
- Chronic use of anti-inflammatory medication except low dose (\< 10mg/d) prednisone and aspirin (\< 100 mg/day);
- Significant cardiac or vascular disease (symptomatic disease or CV event including congestive heart failure within 6 months);
- Significant occlusive atherosclerotic disease or ischemic disease (on non-invasive or invasive diagnostic procedures);
- Significant physical immobility or disabilities (joint replacement, muscular disorders);
- Type I diabetes mellitus, or Type II requiring insulin therapy;
- History of poor adherence to medical regimen;
- Those subjects who have a diagnosis of atrial fibrillation or a pacemaker will be allowed in the study but will not undergo Arterial Tonometry (PWV) studies.
Key Trial Info
Start Date :
October 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2014
Estimated Enrollment :
122 Patients enrolled
Trial Details
Trial ID
NCT01150851
Start Date
October 1 2010
End Date
February 1 2014
Last Update
July 25 2014
Active Locations (4)
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1
Springfield College
Springfield, Massachusetts, United States, 01109-3797
2
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37232
3
Kidney Research Institute
Seattle, Washington, United States, 98104
4
Providence Sacred Heart Medical Research Center
Spokane, Washington, United States, 99204