Status:
COMPLETED
Effects of Magnesium Supplementation on Vascular Structure and Function in Hypertensive Patients
Lead Sponsor:
Rio de Janeiro State University
Collaborating Sponsors:
Rio de Janeiro State Research Supporting Foundation (FAPERJ)
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Conditions:
Hypertension
Endothelial Dysfunction
Eligibility:
FEMALE
40-65 years
Phase:
PHASE4
Brief Summary
Introduction: Magnesium has been the target for many experimental and clinical studies due to the negative correlation between its serum and intracellular levels and the prevalence of hypertension and...
Detailed Description
The main objective of this study is to evaluate whether magnesium supplementation is associated with improved blood pressure control and whether it has beneficial effects on the vascular structure and...
Eligibility Criteria
Inclusion
- Women aged between 40 and 65 years-old
- Hypertension with mild blood pressure elevation:
- Systolic BP between 140 and 159mmHg AND/OR
- Diastolic BP between 90 and 99 mmHg
- Antihypertensive monotherapy with daily use of thiazidic diuretic, at least in the last 30 days
- Signature of the Informed Consent by the patient or his legal representative
Exclusion
- Evidences for secondary hypertension
- Hypertension in stage 2, SBP ≥ 160mmHg and/or DBP ≥ 100mmHg, before the beginning of supplementation
- Blood pressure \> 180 x 100 mmHg in any phase of the study
- Body mass index \> 35 kg/m2
- Diabetes Mellitus
- Renal disease presenting glomerular filtration rate \< 60ml/min
- Coronary artery disease clinically evident with previous episode of myocardial infarction and/or myocardial revascularization
- Clinical signs of heart failure
- History of stroke
- Any condition, disease or therapy that, under investigator's opinion, may influence objectives, results, or put in risk the safety of the patients.
- Pregnancy
- Patients should not be taking any mineral or vitamin supplements
- Gastrointestinal conditions
Key Trial Info
Start Date :
March 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2012
Estimated Enrollment :
52 Patients enrolled
Trial Details
Trial ID
NCT01151683
Start Date
March 1 2010
End Date
November 1 2012
Last Update
January 7 2013
Active Locations (1)
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1
Department of Clinical Medicine, State University of Rio de Janeiro
Rio de Janeiro, Rio de Janeiro, Brazil, 20551030