Status:
COMPLETED
Positive Airway Pressure for the Treatment of Asthma
Lead Sponsor:
Brigham and Women's Hospital
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Asthma
Sleep Apnea
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
Asthma is an extremely common disorder, which is becoming more prevalent. The purpose of this study is to examine how nocturnal lung volumes contribute to asthma severity, which may explain part of th...
Detailed Description
Asthma is a chronic respiratory disease characterized by airway inflammation and airway hyperresponsiveness, which causes airflow obstruction. It is extremely prevalent, affecting an estimated 22 mill...
Eligibility Criteria
Inclusion
- mild to moderate asthma, diagnosed by a physician, OR
- mild to moderate asthma and CPAP treated OSA. Must be compliant with CPAP therapy (greater than 4 hours per night, at least 4 nights/week)
Exclusion
- lung disease other than asthma or OSA
- medications known to affect respiratory function (apart from asthma and rhinitis therapy)
- abnormal nasal anatomy
- current smokers and ex-smokers (quit within the last 3 months, or \>10 pack-years)
- pregnant women - women of child bearing age will undergo a urine pregnancy test before enrollment and during the course of the study, as some of the study procedures cannot be performed during pregnancy and because pregnancy often changes asthma symptoms and severity.
- severe asthma - defined as a recent exacerbation (doctor or ER visit for asthma, or oral steroid use, within the previous 4 weeks) or frequent exacerbations (\>4 exacerbations in the last year.
- severe obstructive sleep apnea requiring supplemental oxygen in addition to CPAP therapy.
- the regular use of prescription (e.g. zolpidem) or over-the-counter sleep aids (e.g. Benadryl).
- Central sleep apnea
Key Trial Info
Start Date :
July 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2014
Estimated Enrollment :
31 Patients enrolled
Trial Details
Trial ID
NCT01154699
Start Date
July 1 2010
End Date
December 1 2014
Last Update
May 17 2017
Active Locations (1)
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1
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115