Status:
COMPLETED
Effective Treatment of Sleep Apnea in Prediabetes to Reduce Cardiometabolic Risk
Lead Sponsor:
University of Chicago
Conditions:
Diabetes
Sleep Apnea
Eligibility:
All Genders
45-75 years
Phase:
NA
Brief Summary
Although obstructive sleep apnea (OSA) is associated with impaired glucose tolerance and diabetes, it remains unclear whether OSA treatment with continuous positive airway pressure (CPAP) has metaboli...
Detailed Description
Although obstructive sleep apnea (OSA) is associated with impaired glucose tolerance and diabetes, it remains unclear whether OSA treatment with continuous positive airway pressure (CPAP) has metaboli...
Eligibility Criteria
Inclusion
- Overweight or obese adults (age ≥45 yrs and BMI ≥25 kg/m2)
- prediabetes and OSA (AHI ≥ 5)
- regular life styles and schedules (no shift work in the past 6 months, no travel across time zones during the past 4 weeks)
- habitual bedtimes of at least 6 hours but not exceeding 9 hours will be eligible.
- not to take any medications during the study period with the exception of antihypertensives and lipid lowering agents
- not on hormone replacement therapy.
- have sedentary activities and no competitive athletes or subjects with high exercise levels.
Exclusion
- previous or current treatment with supplemental oxygen
- requirement of supplemental oxygen or bi-level positive airway pressure for OSA treatment during titration
- presence of active infection, psychiatric disease or history of other significant illness (e.g., myocardial infarction, congestive heart failure, stroke, arrhythmia, chronic kidney or liver disease0
- clinical depression as evidenced by a score \>16 in CES-D scale
- smoking, or routine alcohol use (more than 2 drinks per day), or excessive caffeine intake (\>300mg per day)
Key Trial Info
Start Date :
October 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2012
Estimated Enrollment :
39 Patients enrolled
Trial Details
Trial ID
NCT01156116
Start Date
October 1 2009
End Date
October 1 2012
Last Update
May 27 2015
Active Locations (1)
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1
The University of Chicago
Chicago, Illinois, United States, 60637