Status:
WITHDRAWN
Investigation of Gender Specificity of the Effects of Furosemide in Healthy Female and Male Volunteers
Lead Sponsor:
Universitätsklinikum Hamburg-Eppendorf
Conditions:
Healthy Male and Female Volunteers
Eligibility:
All Genders
18-39 years
Phase:
PHASE4
Brief Summary
In this study the gender specificity of the effects of furosemide in female and male volunteers will be investigated. The main objective is gender-specific comparison of the pharmacokinetic parameters...
Detailed Description
In this study the gender specificity of the effects of furosemide in female and male volunteers will be investigated. The healthy volunteers receive 1. furosemide and 2. aminohippurate sodium "PAH" as...
Eligibility Criteria
Inclusion
- Healthy volunteer for medical history and physical examination findings
- 18 years, \<40 years
- Written informed consent is given
- No clinically relevant changes in laboratory parameters
- Inconspicuous current ECG
- taking medication under a different drug trial within the last 30 days
Exclusion
- concomitant medication at study days or a week before
- allergies or known hypersensitivity reactions to furosemide or aminohippurate sodium
- decreased creatinine clearance by Cockcroft-Gault (\<100 ml / min)
- current drug abuses
- opiate addiction within the last 10 years
- smoking within the last year
- pregnancy and 6 months postpartum, lactation
- deprivation of legal capacity
- Cooperation inability
Key Trial Info
Start Date :
January 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2012
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT01156220
Start Date
January 1 2012
End Date
June 1 2012
Last Update
July 1 2022
Active Locations (1)
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1
Clinical Trial Center North
Hamburg, Germany, 20246