Status:
COMPLETED
Effect of Beta Blockade on Left Ventricular Remodeling and Function in Moderate to Severe Asymptomatic Aortic Regurgitation
Lead Sponsor:
Oslo University Hospital
Collaborating Sponsors:
University Ghent
University Hospital, Gentofte, Copenhagen
Conditions:
Aortic Valve Insufficiency
Eligibility:
All Genders
18-70 years
Phase:
PHASE4
Brief Summary
The primary objective of this study is to evaluate the effect of beta-blocker on left ventricular (LV) remodeling in asymptomatic patients with moderate to severe aortic regurgitation.
Detailed Description
The left ventricle responds to the volume load of chronic aortic regurgitation (AR) with a series of compensatory mechanisms, including an increase in end-diastolic volume, an increase in chamber comp...
Eligibility Criteria
Inclusion
- Moderate to severe aortic valve insufficiency
- Asymptomatic
Exclusion
- Arrhythmia
- Other severe valve disease
Key Trial Info
Start Date :
August 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2014
Estimated Enrollment :
75 Patients enrolled
Trial Details
Trial ID
NCT01157572
Start Date
August 1 2010
End Date
September 1 2014
Last Update
September 25 2014
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