Status:
COMPLETED
Nighttime Dosing of Antihypertensive Drugs in Type 2 Diabetes
Lead Sponsor:
University of Aarhus
Collaborating Sponsors:
Regionshospitalet Silkeborg
The Ministry of Science, Technology and Innovation, Denmark
Conditions:
Diabetes Mellitus, Type 2
Hypertension
Eligibility:
All Genders
30-75 years
Phase:
NA
Brief Summary
The purpose of this study is to investigate if it is possible to lower the nighttime blood pressure in patients with type 2 diabetes mellitus by shifting the administration of antihypertensive drugs f...
Detailed Description
In recent years several studies have shown that high nighttime blood pressure is associated with increased cardiovascular risk independently of the average 24 hour blood pressure. As a consequence the...
Eligibility Criteria
Inclusion
- Type 2 diabetes
- Systolic nighttime blood pressure above 120 mm Hg
- Systolic daytime blood pressure not exceeding 150 mm Hg
- Antihypertensive treatment which must include
- once-daily drugs
- at least one drug must be a Angiotensin-Converting Enzyme Inhibitor, Angiotensin II Receptor Blocker or Renin Inhibitor.
Exclusion
- MI or stroke within 6 months
- heart failure (EF \< 45 %)
- atrial fibrillation
- eGFR \< 30 ml/min
Key Trial Info
Start Date :
August 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2012
Estimated Enrollment :
46 Patients enrolled
Trial Details
Trial ID
NCT01158625
Start Date
August 1 2010
End Date
November 1 2012
Last Update
April 4 2013
Active Locations (2)
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1
Aarhus University Hospital
Aarhus, Denmark, 8000
2
Regional Hospital Silkeborg
Silkeborg, Denmark, 8600