Status:
COMPLETED
Sleepiness and Driving Performances in Adults With Attention-Deficit/ Hyperactivity Disorder (ADHD)
Lead Sponsor:
University Hospital, Bordeaux
Conditions:
Attention Deficit Disorder With Hyperactivity
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
The Attention Deficit/ Hyperactivity Disorder (ADHD) is a developmental disorder which affects 3 to 5 % of school age children. This disorder persists in the adulthood for 60 % of subjects. Children w...
Detailed Description
The main objective of this study is to estimate both the sleepiness by a Maintenance Wakefulness Test (MWT) and the capacity to drive in adults presenting an ADHD. Duration of participation for each p...
Eligibility Criteria
Inclusion
- Group for ADHD:
- Patients, male or female, aged 18 to 60 years
- Patients who met the criteria for current diagnosis of ADD / ADHD according to DSM IV-TR
- Patients who met the criteria for diagnosis in childhood ADD / ADHD, as assessed by the scale "Conners'Adult ADHD Diagnostic Interview for DSM-IV" (CCACID) (Conners, 1997)
- Patients with a total score ≥ 20 at the CAARS (hetero-questionnaire to 30 items) (Conners, 1997) with at least 6 items of inattention or hyperactivity subscale ≥ 2
- Patients deprived from all psychostimulants for 72 hours
- Having been schooled up to last year of middle school
- Having regular hours of life 3 days before entering the study
- Having a driver's license
- Registered Social Security
- Having given their written informed consent to participate in the study
- Consent free, informed and written, dated and signed by the patient and the investigator before any examination required by the research.
- For the apneic group:
- Patients, male or female, aged 18 to 60 years
- Patients with apnea index of apnea / hypopnea\> 10
- Having been schooled up to last year of middle school
- Having regular hours of life 3 days before entering the study
- Having a driver's license
- Registered Social Security
- Having given their written informed consent to participate in the study
- Consent free, informed and written, dated and signed by the patient and the investigator before any examination required by the research
- For the control group:
- Participant male or female, aged 18 to 60 years
- Participant not symptomatic of ADHD (total score WURS less than 46 of the 25 questions about ADHD, and at least four more crosses in the boxes shaded the first 6 issues of ASRS)
- Participant with no complaints of sleep, or excessive daytime sleepiness (no item equal to 4 or 5 to BNSQ, except for items 16 and 17 (for snoring) and ESS total score below 11)
- Participant with an AHI \<10 and MPS index \<15 in ambulatory polygraph during the night of selection
- Participant with an AHI \<10 and MPS Index \<15 after overnight polysomnography in the laboratory prior to the day of testing
- Having been schooled until the third class,
- Having regular hours of life 3 days before entering the study,
- Having a driver's license,
- Registered Social Security,
- Having given their written informed consent to participate in the study
- Consent free, informed and written, dated and signed by the participant and the investigator before any examination required by the research.
Exclusion
- Posted or Night worker,
- Any evolutionary neurological disorders (brain tumour, epilepsy, migraine, brain vascular accident, multiple sclerosis, myoclonus, chorea, neuropathy, muscular dystrophies, myotonic dystrophy),
- Psychiatric comorbidity: current major depressive episode, current hypo obsessive or obsessive episode, schizophrenia,
- Renal Disorders (renal insufficiency, nephrolithiases),
- Endocrine Pathologies (dysthyroid, diabetes),
- Drug addiction
- Alcoholic Dependence during the last 6 months,
- Dependence in the tetra-hydroxy-cannabinol
- Long-term Treatment by benzodiazépines
- Treatment by atomoxétine
- Persons placed under protection of justice
Key Trial Info
Start Date :
July 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2013
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT01160874
Start Date
July 1 2010
End Date
July 1 2013
Last Update
October 25 2013
Active Locations (2)
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1
CHU de Bordeaux
Bordeaux, France, 33076
2
Hôpital Charles Perrens
Bordeaux, France, 33076