Status:
COMPLETED
Brain MRI (Magnetic Resonance Imaging) Scans of Patients With Treatment Resistant Depression (TRD) and Healthy Controls
Lead Sponsor:
University of Bristol
Collaborating Sponsors:
North Bristol NHS Trust
Conditions:
Mental Disorders
Eligibility:
All Genders
26-64 years
Brief Summary
Treatment resistant depression (TRD) is a major health concern, with 10% of patients with major depressive disorder not responding to conventional treatments. The investigators propose to compare the ...
Detailed Description
All the patients treated at Frenchay Hospital, UK, with deep brain stimulation (DBS) for treatment resistant depression (TRD) will be given a Patient Information Sheet, and asked if they would like to...
Eligibility Criteria
Inclusion
- Up to 12 females and 4 males, sex, handedness and age (±5 years) matched for the DBS patients.
Exclusion
- Current or past psychiatric disorder as assessed with MINI and clinical interview.
- Significant head injury.
- Standard MRI risk criteria (metallic clips or pins in body, pacemaker, aneurysm clips, pregnancy, possibility of metal in eyes including history of traumatic eye injury, shrapnel or bullet injuries).
- Inability to lie in the scanner for whatever reason (e.g. claustrophobia).
- Current acute medical illness.
- Started on new medicines in the last two months that the investigator feels may interfere with the study.
- Any medical condition that in the principle investigator's opinion is not matched in the DBS sample (e.g. epilepsy, diabetes, cardiac/hepatic/renal failure but not hypertension).
- The investigator feels that the volunteer is unsuitable for the research protocol, or unable or unwilling to comply with study procedures.
Key Trial Info
Start Date :
February 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 1 2012
Estimated Enrollment :
21 Patients enrolled
Trial Details
Trial ID
NCT01162434
Start Date
February 1 2010
End Date
February 1 2012
Last Update
July 12 2012
Active Locations (1)
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1
Bristol Royal Infirmary
Bristol, United Kingdom, BS2 8HW