Status:
UNKNOWN
The Biology of Chronic Preconditioning: Genomic and Physiologic Mechanisms of Response
Lead Sponsor:
The Hospital for Sick Children
Conditions:
Ischemic Preconditioning
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
The purpose of this study is to assess the effects of repeated RIPC and exercise, on exercise performance, skeletal muscle responses and circulating cellular and humoral biology in humans
Detailed Description
Remote ischemic preconditioning (RIPC) results in a powerful and widespread protective effect against subsequent prolonged ischemia-reperfusion (IR) injury of distant organs and systemic inflammatory ...
Eligibility Criteria
Inclusion
- Age ≥ 18 years,
- Informed consent
Exclusion
- Contraindication to exercise,
- Vigorous aerobic/anaerobic exercise in duration of ≥15 minutes during the 21 days prior to commencement of the study, or either of the RIPC or exercise protocol arms,
- Overt viral or bacterial infection in the 10 days prior to commencement of the study, or during either of the RIPC or exercise protocol arms,
- Alcohol and/or caffeine consumption in the 10 days prior to, or at any time during the study period
- Pregnancy
Key Trial Info
Start Date :
May 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2014
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT01164618
Start Date
May 1 2010
End Date
January 1 2014
Last Update
August 15 2013
Active Locations (1)
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1
The Hospital for Sick Children
Toronto, Ontario, Canada, M5G 1X8