Status:
UNKNOWN
Comparison Between High-flow Nasal Cannula System and Non-invasive Ventilation in Acute Hypoxemic Respiratory Failure
Lead Sponsor:
Asan Medical Center
Conditions:
Acute Hypoxemic Respiratory Failure
Eligibility:
All Genders
18+ years
Phase:
PHASE2
PHASE3
Brief Summary
Acute hypoxemic respiratory failure may require invasive mechanical ventilation. However, invasive mechanical ventilation is associated with a variety of complications. Non-invasive ventilation has be...
Eligibility Criteria
Inclusion
- Age above 18
- patients with acute hypoxemic respiratory failure
Exclusion
- age \< 18 years
- hypercapnia (arterial carbon dioxide tension (PaCO2) \>45mmHg) at admission
- need for emergency intubation, including cardiopulmonary resuscitation
- recent esophageal, facial or cranial trauma or surgery
- severely decreased consciousness (Glasgow coma score \<11)
- cardiogenic shock or severe hemodynamic instability
- systolic blood pressure \<90 mmHg associated with decreased urinary output(\<20 mL.h-1) despite fluid repletion and use of vasoactive agents
- lack of co-operation
- altered mental status with decreased consciousness and/or evidence of inability to understand or lack of willingness to co-operate with the procedures
- tracheotomy or other upper airway disorders
- severe ventricular arrhythmia or active myocardial ischemia
- active upper gastrointestinal bleeding
- inability to clear respiratory secretions
- more than one severe organ dysfunction in addition to respiratory failure
Key Trial Info
Start Date :
July 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
74 Patients enrolled
Trial Details
Trial ID
NCT01166256
Start Date
July 1 2010
Last Update
July 21 2010
Active Locations (1)
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1
Asan Medical Center, University of Ulsan College of Medicine
Seoul, South Korea