Status:
COMPLETED
Short (5 Days) Versus Long (14 Days) Duration of Antimicrobial Therapy for Acute Bacterial Sinusitis in Children
Lead Sponsor:
University of Wisconsin, Madison
Collaborating Sponsors:
Thrasher Research Fund
Conditions:
Sinusitis
Eligibility:
All Genders
1-10 years
Phase:
NA
Brief Summary
The investigators objective is to compare short course (5 days) to long course (14 days)antibiotics for the treatment of acute bacterial sinusitis in children. The investigators hypothesize that short...
Detailed Description
This was a prospective, randomized, double-blind study comparing short course (5 days) to long course (14 days) antimicrobial therapy for children between 1 and 10 years of age with acute bacterial si...
Eligibility Criteria
Inclusion
- children with nasal discharge (of any quality) or daytime cough (which may be worse at night) or both persisting for 10 days or more without evidence of improvement.
- families need to be English speaking
Exclusion
- used antibiotics within the last 15 days;
- had symptoms for \> 30 days;
- have concurrent streptococcal pharyngitis or acute otitis media (as the standard doses for both of these conditions is 10 days);
- are allergic to penicillin;
- have symptoms that suggest a complication due to acute bacterial sinusitis that necessitates hospitalization, intravenous antibiotics or sub-specialty evaluation
- been diagnosed with either immunodeficiency or anatomic abnormality of the upper respiratory tract
- history of recurrent acute sinusitis (more than 3 episodes in 6 months or 4 episodes in a year)
- history of chronic sinusitis (more than 90 days of respiratory symptoms in this or the previous respiratory season)
- girls who have begun menstruating
Key Trial Info
Start Date :
November 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2016
Estimated Enrollment :
98 Patients enrolled
Trial Details
Trial ID
NCT01166945
Start Date
November 1 2010
End Date
February 1 2016
Last Update
June 10 2019
Active Locations (2)
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1
UW Health Pediatrics (Park St)
Madison, Wisconsin, United States, 53715
2
UW Health Pediatrics (WestTowne)
Madison, Wisconsin, United States, 53717