Status:
COMPLETED
Changes in Refractory Acute Respiratory Distress Syndrome (ARDS) Patients Under High Frequency Oscillation-ventilation
Lead Sponsor:
Centre Hospitalier Universitaire de la Réunion
Conditions:
Respiratory Distress Syndrome, Adult
Eligibility:
All Genders
18+ years
Brief Summary
The study is intended to evaluate the hemodynamic and the indexed extrapulmonary lung water (ELWI) changes in patients treated by high frequency oscillation-ventilation (HFO-V) for refractory acute re...
Detailed Description
All ARDS patients will be treated according to a strictly defined protocol. Each patient will receive a standardised sedation with sufentanil, midazolam and atracurium. Tidal volume was adjusted on 6m...
Eligibility Criteria
Inclusion
- At least 18 years old
- Admission in ICU
- Transpulmonary PiCCO-technique monitoring
- Refractory ARDS (ratio PaO2/FiO2 \< 120) after 12 hours of protective mechanical ventilation with maximal PEEP recruitment (inclusion is possible before this 12hours delay if the patient's status is worsening under optimised ventilation parameters AND plateau pressure above 30cm H2O OR saturation \<88%)
- Choice of HFO-V as ventilation rescue technique
- Hemodynamic stability at plugging (after fluid challenge or norepinephrine if necessary)
Exclusion
- Arteritis, hemostasis disorder
- Pneumothorax,
- Acute cardiac failure indicating a ECLS
- Previous use of other rescue techniques (Nitrous oxide, prone ventilation, ECMO)
Key Trial Info
Start Date :
September 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 1 2012
Estimated Enrollment :
23 Patients enrolled
Trial Details
Trial ID
NCT01167621
Start Date
September 1 2010
End Date
September 1 2012
Last Update
July 29 2015
Active Locations (1)
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1
Réanimation polyvalente, University Hospital Reunion Island - Felix Guyon Site
Saint Denis de La Réunion, France, 97405