Status:
COMPLETED
Autologous Bone Marrow Derived Stem Cells for Acute Myocardial Infarction
Lead Sponsor:
Royan Institute
Conditions:
Myocardial Infarction
Eligibility:
All Genders
18-75 years
Phase:
PHASE3
Brief Summary
One of the important reasons for human dying is Ischemic heart disease (IHD). The most reason is coronary artery disease. Beside morbidity, IHD induce myocardial infarction and necrosis which due to c...
Eligibility Criteria
Inclusion
- CABG candidate
- At least 4 akinetic segments
- First anterior heart attack within in 10 days to 3 month.
- St elevation MI defined by: Post Acute MI LVEF less than 45% as assessed by echocardiography.
- The target lesion had to be located in the left anterior descending (LAD) section.
Exclusion
- History of prior anterior myocardial infarction:
- History of prior CABG
- Poor echocardiography window.
- Active infection or history of recurrent infection or positive test for syphilis (RPR), hepatitis B and C (HBSAg/ Anti HBc Anti - Hcv) HIV and HTLV-l
- Documental terminal illness or malignancy.
- Previous bone marrow transplant
- Autoimmune disease (e. g Lupus, Multiple sclerosis)
- Any contraindication for bone - marrow aspiration.
- Positive pregnancy test (in women with child bearing potential)
Key Trial Info
Start Date :
January 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2012
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT01167751
Start Date
January 1 2008
End Date
July 1 2012
Last Update
June 21 2016
Active Locations (1)
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1
Royan Institute
Tehran, Tehran Province, Iran