Status:
COMPLETED
Effect of Valproate on Propofol
Lead Sponsor:
Okayama University
Conditions:
Mental Retardation
Eligibility:
All Genders
16+ years
Brief Summary
The aim of this study is to evaluate the effect of valproate on the required dose of propofol for sedation in patients with mental retardation.
Detailed Description
The intravenous sedation with propofol is very useful for patients with mental retardation and challenging behavior. However, it is very difficult to titrate the dose of propofol for maintaining the a...
Eligibility Criteria
Inclusion
- Patients aged 16 or over
- American Society of Anesthesiologists (ASA) physical status 1 or 2
- The treatment of dental caries, endodontics, periodontics and prosthesis were planed
- Participants had moderate or severe Mental Retardation, and were not completely cooperated with dental treatment
Exclusion
- Patients could communicate and cooperate with dental treatment, but used dental sedation for decrease of the anxiety and the fear about dental treatment or another reasons
- Patients needed premedication and inhalational anesthetics
- Patients had uncontrolled or sever medical condition
Key Trial Info
Start Date :
April 1 2007
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
August 1 2010
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT01170377
Start Date
April 1 2007
End Date
August 1 2010
Last Update
October 21 2015
Active Locations (1)
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1
Department of Dental Anesthesiology and Special Care Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Okayama, Japan