Status:
COMPLETED
Psoriasis Inflammation and Systemic Co Morbidities
Lead Sponsor:
Rockefeller University
Collaborating Sponsors:
Weill Medical College of Cornell University
Conditions:
Psoriasis
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
Psoriasis is a chronic relapsing prevalent inflammatory disease affecting 2-4% of the world's population. Severe psoriasis is a disabling disease affecting the physical and emotional well being of pat...
Detailed Description
Psoriasis is the most prevalent immune-mediated skin disease affecting 2-4% of the world's population. Severe psoriasis is a disabling disease affecting the physical and emotional well being of patien...
Eligibility Criteria
Inclusion
- Age ≥ 18years
- Psoriasis affecting Body Surface Area (BSA) ≥ 10% after washout
- No systemic anti psoriatic therapy ≤ 30days
- Plaque type Psoriasis
Exclusion
- Overt diabetes (\> 135 mg/dL fasting blood glucose on two (2) separate occasions
- Hypertension as defined as a systolic BP \> 140 \&/or a diastolic pressure \> 90. -Cannot be on more then one (1) antihypertensive medication.
- Currently have any known malignancy or have a history of malignancy in the 5 past years excluding basal cell carcinoma.
- S/P Cardiovascular event such as Myocardial infarction, any open heart surgery, stroke or other vascular occlusive event.
- Known allergy to etanercept
- HIV positive
- HBV positive
- HbA1C \>7
- Current use of hypoglycemic medication
- Current use of any anticoagulants
- Current use of any anti-inflammatory medications (except inhaled steroids)
- Females of childbearing age who are pregnant or breast-feeding or not using a contraceptive.
- NYHA Class III and Class IV heart failure
- Positive PPD
- History, physical, or laboratory findings suggestive of any other medical or psychological condition that would, in the opinion of the Principal Investigator, make the candidate ineligible for the study.
Key Trial Info
Start Date :
July 13 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 9 2013
Estimated Enrollment :
29 Patients enrolled
Trial Details
Trial ID
NCT01170715
Start Date
July 13 2010
End Date
September 9 2013
Last Update
February 8 2021
Active Locations (1)
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1
The Rockefeller University
New York, New York, United States, 10065