Status:
COMPLETED
To Evaluate if Wide Blood Sugar Fluctuations Lead to Injury of Heart Function and Heart Nerves
Lead Sponsor:
University of Michigan
Conditions:
Type 1 Diabetes Mellitus
Eligibility:
All Genders
18-65 years
Brief Summary
This proposal will test if, in patients with type 1 diabetes, wide blood glucose fluctuations lead to the injury to heart nerves , called cardiac autonomic neuropathy (CAN), and to impaired heart cont...
Eligibility Criteria
Inclusion
- Inclusion/Exclusion Criteria:
- Male or female between the ages 18-65, with type 1 diabetes of 5-10 years duration who are free of complications and age-and-sex-matched healthy control volunteers.
- Hemoglobin A1c greater than 7 %. (For Type 1 diabetics)
- If you are a woman of childbearing potential you must agree to use an acceptable birth control method throughout the duration of the study. The methods of birth control that you can use are: Oral contraceptives (birth control pill), IUD or a barrier method (e.g. diaphragm or condom with spermicide).
- You should have no history of any cardiovascular disease including any form of coronary artery disease, congestive heart failure, known arrhythmias (irregular heart beats), valvular disease or high blood pressure.
- If you have any pacemaker or ICD, if you have any metallic foreign body such as surgical implants or clips or foreign bodies in the eye or orbits, wearing medication patches containing foil, or any other metal in the body or if you are claustrophobic you cannot participate in this study.
- You should be free of any diabetic complications (e.g. nephropathy or kidney damage, retinopathy or eye damage), have no history of previous kidney, pancreas or cardiac transplantation, any other severe chronic illness that has neuropathy (numbness, burning or tingling) and/or neurologic disease as a recognized complication (e.g. Parkinson's disease, epilepsy), or any other serious medical conditions that may shorten life span (e.g. disabling stroke, Chronic Obstructive Pulmonary Disease).
- You should be free of any malignancy other than basal cell skin cancer.
- No history of alcohol abuse.
- You should not use any agents or drugs that interfere with the imaging techniques described below.
- You must be able to cooperate with the test protocols that are described below and be willing to sign this consent form.
- Inclusion for Control group:
- BMI \<30
- If female, must not be pregnant or nursing
- Normal blood pressure
- Normal labs-(glucose and lipids)
Exclusion
Key Trial Info
Start Date :
May 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
August 1 2016
Estimated Enrollment :
55 Patients enrolled
Trial Details
Trial ID
NCT01170832
Start Date
May 1 2010
End Date
August 1 2016
Last Update
August 27 2018
Active Locations (1)
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1
University Of Michigan
Ann Arbor, Michigan, United States, 48106