Status:
COMPLETED
"WB-DCE-MRI" in Multiple Myeloma as an Independent Prognostic Factor for Disease-free Survival
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Multiple Myeloma
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
The main objective of this study is to examine if absence of a satisfactory response on DCE-WB-MRI (see MR criteria of responders section) after completion of HDT followed by autologous stem-cell tran...
Detailed Description
Introduction Bone marrow angiogenesis is increased in multiple myeloma (MM) and is an important prognostic factor for survival. Newly diagnosed MM patients have higher microvessel density (MVD) than c...
Eligibility Criteria
Inclusion
- Patient referred to one of the hematology departement associated with the research project, with confirmed multiple myeloma defined according to uniform international criteria.
- Whatever stage classification according to Salmon and Durie with a life expectancy of more than 3 months.
- Age under 70 years old (amendment n°5) and eligible for autologous stem cell transplantation.
- Free and informed consent.
Exclusion
- Patient unfit physically, mentally or legally to give informed consent.
- Patient non affiliate with social security scheme
- Patient with myeloma without measurable monoclonal immunoglobulin, including measurement of serum free light chains.
- Patient with another malignancy excluding basal cell cancer.
- Patient who could not undergo MRI (incompatible metallic foreign body, pacemaker, allergy to contrast, claustrophobia despite premedication, pregnancy, renal failure with creatinine clearance \<30 ml/min
Key Trial Info
Start Date :
July 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2019
Estimated Enrollment :
104 Patients enrolled
Trial Details
Trial ID
NCT01171430
Start Date
July 1 2010
End Date
February 1 2019
Last Update
November 20 2020
Active Locations (1)
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1
Henri Mondor Hospital
Créteil, France, 94010