Status:
COMPLETED
The Effect of Melatonin on Ischemia-reperfusion Injury Following Acute Myocardial Infarction
Lead Sponsor:
Herlev Hospital
Conditions:
Acute Myocardial Infarction
Ischemia-reperfusion Injury
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
In Denmark, 12.000 people a year, is struck by acute myocardial infarction. A third of these cannot be saved before treatment is possible. Despite quick and effective reperfusion of the coronary arte...
Detailed Description
Purpose The purpose of this Ph.D study is to examine the antioxidative effect of melatonin in relation to ischemia-reperfusion injury. The investigators wish to examine to which extend melatonin admi...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Adults who are able to give informed consent
- 1 significant coronary occlusion (\>2mm) with TIMI 0-1 expected to undergo PCI.
- The occlusion must be ECG-verified with new ST-elevations ≥ 0.2 mV in V2-V3 and/or ≥ 0.1 in the other leads or a new onset left bundle branch block.
- Having onset of symptoms of qualifying AMI and undergo PCI within 6 hours.
- If the patients do not fulfill the ECG inclusion criteria they can still be included if the primary PCI reveals an acute coronary occlusion (\>2mm) with TIMI 0-1.
- Exclusion criteria:
- Patients with prior myocardial infarction
- more than one significant occlusion
- prehospital thrombolysis
- known history of renal failure
- history of autoimmune diseases
- pregnancy, fertile women or breastfeeding
- severe concurrent illness with reduced short-term prognosis
- pacemaker
- claustrophobia
- cardiogenic shock
- metals in the body
- atrial fibrillation
- BMI ≥ 40.
Exclusion
Key Trial Info
Start Date :
June 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2016
Estimated Enrollment :
41 Patients enrolled
Trial Details
Trial ID
NCT01172171
Start Date
June 1 2013
End Date
December 1 2016
Last Update
January 4 2017
Active Locations (2)
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1
Aalborg University Hospital
Aalborg, Aalborg, Denmark, 9000
2
Odense University Hospital
Odense, Odense, Denmark, 5000