Status:
COMPLETED
Effects of Essential Amino Acid Intake on Net Protein Synthesis in Weight-losing Non-small Cell Lung Cancer Patients
Lead Sponsor:
Texas A&M University
Collaborating Sponsors:
University of Arkansas
Conditions:
Non-small Cell Lung Cancer
Eligibility:
All Genders
40+ years
Phase:
NA
Brief Summary
Weight loss commonly occurs in lung cancer patients, negatively influencing their quality of life, treatment response and survival. Gains in lean body mass are difficult to achieve in cancer unless sp...
Detailed Description
In this study, we will test the following hypothesis: A high-leucine essential amino acid mixture stimulates whole body protein synthesis (and in this way protein anabolism) to a larger extent than a ...
Eligibility Criteria
Inclusion
- Recently diagnosed with Stage III (unresectable) or Stage IV lung cancer (only for the NSCLC group)
- Ability to sign informed consent
- Age 40 years and older
Exclusion
- Previous anti-cancer therapy (e.g. radiotherapy, chemotherapy) or surgery less than 4 weeks prior to the experiment.
- Presence of fever within the last 3 days
- Established diagnosis of Diabetes Mellitus
- BMI \> 35 kg/m2
- Untreated metabolic diseases including hepatic or renal disorder
- Presence of acute illness or metabolically unstable chronic illness
- Use of long-term oral corticosteroids or short course of oral corticosteroids in the preceding month before enrollment
- Diagnosis of moderate to severe chronic airflow limitation, defined as measured forced expiratory volume in one second (FEV1) ≤ 70% of referen¬ce FEV1 (only for the healthy control group)
- Use of supplements enriched with amino acids
- Any other condition according to the PI or study physicians would interfere with proper conduct of the study / safety of the patient
- Failure to give informed consent
Key Trial Info
Start Date :
July 13 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 22 2012
Estimated Enrollment :
41 Patients enrolled
Trial Details
Trial ID
NCT01172314
Start Date
July 13 2010
End Date
February 22 2012
Last Update
September 30 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University of Arkansas for Medical Sciences
Little Rock, Arkansas, United States, 72205