Status:
UNKNOWN
Optimal Concentration of Dermatophagoides Pteronyssinus (Dp) Allergen Extract for Skin Prick Test (SPT) of Thai Population
Lead Sponsor:
Siriraj Hospital
Conditions:
Rhinitis, Allergic, Perennial
Rhinitis, Allergic, Seasonal
Eligibility:
All Genders
15-60 years
Brief Summary
The purpose of this study is to determine the appropriate concentration of diagnostic reagent of house dust mite (Dp) to be used in diagnostic allergy skin prick test among Thai population with allerg...
Detailed Description
The current allergy diagnostic reagent of house dust mites marketed in the USA is at 10,000 AU/ml. This is based on the IDEAL50 concept put forth by Turkeltaub et al, almost 3 decades ago. Such concen...
Eligibility Criteria
Inclusion
- allergic rhinitis
- clinical diagnosis of allergic rhinitis
- has skin prick test positive to standard Dp extract (wheal diameter 3 mm. or greater)
- not take any medications that interfere the tests (skin prick test and nasal allergen provocation test)
- healthy subject
- no underlying disease
- not take any medications that interfere the tests (skin prick test and nasal allergen provocation test)
Exclusion
- has skin prick test positive to standard Dp extract with wheal diameter more than 10 mm.
- has chronic disease eg. HIV infection, neurological diseases, hypertension, cardiac diseases, pulmonary diseases, hepatobiliary diseases, renal diseases, endocrinological diseases, congenital malformation, malignancy
- if has asthma, uncontrolled asthma symptom or PEF \< 70%
- during pregnancy or lactation
- has chronic skin disease
- participate other project within 30 days
- has abnormal anatomy of the nose
Key Trial Info
Start Date :
June 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
110 Patients enrolled
Trial Details
Trial ID
NCT01172613
Start Date
June 1 2010
Last Update
July 30 2010
Active Locations (2)
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1
Siriraj Hospital
Bangkok, Thailand, 10700
2
Siriraj Hospital
Bangkok, Thailand, 10700