Status:
COMPLETED
Effect of Amiodarone on the Procedure Outcome in Long-standing Persistent Atrial Fibrillation Undergoing Pulmonary Vein Antral Isolation
Lead Sponsor:
Texas Cardiac Arrhythmia Research Foundation
Collaborating Sponsors:
University of Kansas
California Pacific Medical Center
Conditions:
Atrial Fibrillation
Eligibility:
All Genders
18-75 years
Phase:
PHASE3
Brief Summary
This prospective randomized study aims to investigate the effect of continuous versus interrupted use of Amiodarone on the procedure outcome in long-standing persistent (LSP) atrial fibrillation patie...
Detailed Description
Background: Atrial Fibrillation (AF) is the most prevalent sustained clinical arrhythmia encountered in clinical practice. Its prevalence is 0.4-1% in the general population and greater than 8% in ind...
Eligibility Criteria
Inclusion
- History of LSP AF
- Age \> 18 years
- Willing and ability to understand and sign an informed consent
- Patients on chronic Amiodarone therapy (≥ 3 months)
Exclusion
- Unstable angina
- Concomitant treatment with other class I or III antiarrhythmic drugs
- Myocardial infarction within past 3 months)
- Presence of any disease that is likely to shorten life expectancy to \< 1 year
- Symptomatic heart failure, NYHA III or IV
- Contraindications for Amiodarone
- Chronic liver diseases
- Pregnant or breast-feeding mothers
Key Trial Info
Start Date :
October 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2014
Estimated Enrollment :
176 Patients enrolled
Trial Details
Trial ID
NCT01173809
Start Date
October 1 2010
End Date
July 1 2014
Last Update
August 21 2014
Active Locations (1)
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1
St.David's Medical Center
Austin, Texas, United States, 78705