Status:
COMPLETED
Insulinotropic Effect of GIP and GLP-1 Before and After Reduced Glucose Tolerance
Lead Sponsor:
Glostrup University Hospital, Copenhagen
Collaborating Sponsors:
University of Copenhagen
European Foundation for the Study of Diabetes
Conditions:
Insulin Resistance
Deteriorated Glucose Homeostasis
Eligibility:
MALE
18-35 years
Phase:
NA
Brief Summary
The incretin effect in patients with type two diabetes is reduced. The investigators have previously shown that it is possible to induce a defect in the incretin effect in healthy individuals. The pur...
Detailed Description
The incretin effect in patients with type two diabetes is reduced. The investigators have previously shown that it is possible to induce a defect in the incretin effect in healthy individuals. The pur...
Eligibility Criteria
Inclusion
- Caucasians without type 2 diabetes mellitus
- Normal OGTT (75 g of glucose) according to WHO's criteria
- BMI 20-30
- Hemoglobin \> 8.0 mmol/l
- Informed consent
Exclusion
- Liver disease (ALAT \> 2 x normal level)
- Nephropathy (s-creatinin \> 130 µM or albuminuria)
- Relatives (parents/siblings) with T2DM
- Medical treatment witch cannot be stopped for 12 hours
Key Trial Info
Start Date :
April 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2010
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT01173978
Start Date
April 1 2010
End Date
July 1 2010
Last Update
June 21 2011
Active Locations (1)
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1
Department of Clinical Physiology
Glostrup Municipality, Denmark, DK-2600