Status:
UNKNOWN
The Effect Of Remote Limb Ischemic Preconditioning For Carotid Artery Stenting
Lead Sponsor:
Capital Medical University
Conditions:
Stroke
TIA
Eligibility:
All Genders
40-80 years
Phase:
PHASE1
Brief Summary
Remote limb ischemic preconditioning is neuro-protective and anti-inflammatory for ischemia- reperfusion injury. As the extent of its effect is unknown, the investigators will use clinical outcome, se...
Detailed Description
BACKGROUND: Brain ischemia and injury contributed to perioperative morbidity and mortality in Carotid Artery Stenting. Remote ischemic preconditioning (RIPC) is a phenomenon whereby brief periods of i...
Eligibility Criteria
Inclusion
- Patients referred for elective Carotid Artery Stenting were participate in the study at the time of scheduling for operation.
- Symptomatic patient, as evidenced by transient ischemic attack (TIA), amaurosis fugax, minor or non-disabling stroke(in the hemisphere supplied by the target vessel), within 180 days of the randomization date.
- Discrete lesion located in the internal carotid artery(ICA), and the degree of carotid stenosis ≥50% defined as:
- Stenosis ≥70% by ultrasound. Stenosis ≥50% by angiography (based on NASCET Criteria)
- Appropriate for carotid stenting. Candidates for Carotid Artery Stenting meet all other inclusion requirements.
Exclusion
- Evolving stroke
- Untoward reaction to anesthesia
- Intolerance or allergic reaction to associated medications, including aspirin(ASA) and clopidogrel.
- Prior major ipsilateral stroke that may confound study endpoints.
- Severe dementia.
- Hemorrhagic transformation of an ischemic stroke within the past 60 days.
- Chronic atrial fibrillation.
- MI within previous 30 days.
- High risk surgical candidate defined as the CREST test.
- Bilateral upper limb arteries are severe stenotic or occlusion.
Key Trial Info
Start Date :
July 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT01175876
Start Date
July 1 2010
Last Update
August 6 2010
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Yumin Luo
Beijing, Beijing Municipality, China, 100053