Status:
TERMINATED
Oxidative Stress Links Aging, Activity, and Mobility Limitation
Lead Sponsor:
VA Office of Research and Development
Collaborating Sponsors:
University of Utah
Conditions:
Aging
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The purpose of this study is to understand why and how oxidative stress negatively impacts mobility in the elderly, and to determine whether antioxidant supplements can increase vascular health and mo...
Detailed Description
With the premise that U.S. Veteran demographics reveal an aging population with significant mobility limitation and oxidative stress is tightly linked to both of these characteristics, a series of ske...
Eligibility Criteria
Inclusion
- Healthy men and women aged either between 18 - 30 years (young group) and \>70 years (old group)
- Free of overt disease. Subjects will be non-obese (BMI \< 30) and have plasma glucose concentrations \< 7.0 mmol/L under fasting conditions and \< 11.1 mmol/L at 120 minutes of an oral glucose tolerance test (OGTT)
- Subjects will be sedentary, defined here as no regular physical activity for at least the prior 2 years
- Candidates must have no orthopedic limitations that would prohibit them from performing cycle or knee-extensor exercise
- All women will be postmenopausal (either natural or surgical) defined as a cessation of menses for at least 2 years, and in women without a uterus, follicle stimulating hormone (FSH) \> 40 IU/L
Exclusion
- Candidates demonstrating dyslipidemia based on the National Cholesterol Education Program Guidelines of plasma total cholesterol \> 240 mg/dl with LDL-cholesterol \> 160 mg/dl will be excluded from participation
- Candidates who smoke or are taking medications (blood pressure medications, statins, antioxidants etc.) that could influence the results of the study will not be eligible
- In terms of diet, subjects will be asked to maintain a dietary record for one week prior to the pre-screening and if this reveals a diet that differs substantially from the "typical" average diet in both the young and old, the subject will not be eligible
- Women currently taking hormone replacement therapy (HRT) in the preceding year will be excluded from the proposed studies
Key Trial Info
Start Date :
July 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 3 2017
Estimated Enrollment :
87 Patients enrolled
Trial Details
Trial ID
NCT01177189
Start Date
July 1 2011
End Date
July 3 2017
Last Update
February 21 2019
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