Status:
COMPLETED
Assessment of Children With Tic Onset in the Past 6 Months
Lead Sponsor:
Washington University School of Medicine
Collaborating Sponsors:
National Institute of Mental Health (NIMH)
Conditions:
Tourette Syndrome
Tourette's Disorder
Eligibility:
All Genders
5-10 years
Brief Summary
The purpose of this research is to study why most children who have tics never develop Tourette syndrome but some do. In other words, we aim to find features that may predict whose tics will go away a...
Detailed Description
Up to 30% of all children will have a tic at some point. However, tics that last a whole year (or more) occur in only 3% of the population. Thus tic persistence may be more unusual than tic onset, yet...
Eligibility Criteria
Inclusion
- \*\* All subjects \*\*
- Inclusion Criteria:
- Age 5-10
- Informed consent from a parent and assent from the child.
- New Tics Group \*\*
- Inclusion Criteria:
- tics now, but developed them only in the past 9 months.
- Exclusion criteria: secondary tics, another neurological disorder (not counting migraine), structural brain disease, severe systemic illness, nonproficiency in the English language, and psychiatric illness including mental retardation, autism, substance dependence, current substance abuse, primary psychotic illness, bipolar disorder and current major depression. Psychoactive medications are allowed if their dose has not changed in the past month.
- \*\* Existing TS/CTD control group \*\*
- Inclusion criteria:
- children who meet DSM-5 criteria for Tourette's Disorder or Persistent Tic Disorder at enrollment
- matched to children from the New Tics group on age (within 1 year), sex, handedness, and ADHD status.
- Exclusion criteria: same as for the New Tics group.
- \*\* Tic-free controls \*\*
- Inclusion criteria: tic-free children matched to children from the New Tics group on age (within 1 year), sex, handedness, and ADHD status.
- Exclusion criteria: current or past tic disorder in the subject or a first-degree relative, plus the exclusions listed for the New Tics group.
Exclusion
Key Trial Info
Start Date :
August 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 13 2023
Estimated Enrollment :
99 Patients enrolled
Trial Details
Trial ID
NCT01177774
Start Date
August 1 2010
End Date
July 13 2023
Last Update
November 27 2023
Active Locations (1)
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1
Washington University School of Medicine, Movement Disorder Clinic
St Louis, Missouri, United States, 63110