Status:
COMPLETED
Carotid Plaque Characteristics by MRI in AIM-HIGH (Carotid MRI Substudy)
Lead Sponsor:
University of Washington
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Coronary Artery Disease
Carotid Artery Diseases
Eligibility:
All Genders
45+ years
Brief Summary
Heart attacks and strokes caused by the unstable atherosclerotic plaques remain the leading cause of death in the United States. Unstable plaques often have more fat than stable plaques. This study wi...
Detailed Description
Although studies have suggested that plaque morphology and composition are important determinants of plaque stability, our understanding on plaque tissue components is mainly from histological studies...
Eligibility Criteria
Inclusion
- Eligible for main AIM-HIGH study (NCT00120289)
- Medically able to undergo MRI procedure
- Willing to provide informed consent for participation in this substudy
Exclusion
- Uses pacemaker or has metallic implants
- History of bilateral carotid endarterectomy
- Glomerular filtration rate less than 60 mL/min/1.73 m\^2
Key Trial Info
Start Date :
March 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 1 2015
Estimated Enrollment :
230 Patients enrolled
Trial Details
Trial ID
NCT01178320
Start Date
March 1 2008
End Date
February 1 2015
Last Update
February 9 2018
Active Locations (19)
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1
Cardiovascular Consultants
Phoenix, Arizona, United States, 85032
2
Long Beach VA Medical Center
Long Beach, California, United States, 90822
3
University of Southern California
Los Angeles, California, United States, 90033
4
University of Maryland
Baltimore, Maryland, United States, 21201