Status:
TERMINATED
Esmolol Infusion During Laminectomy: Effect on Quality of Recovery
Lead Sponsor:
Cedars-Sinai Medical Center
Conditions:
Laminectomy
Eligibility:
All Genders
18-80 years
Phase:
PHASE4
Brief Summary
The purpose of this study is to evaluate the effects of esmolol, a drug which is commonly administered during surgery to help control blood pressure and heart rate, on postoperative pain levels and re...
Detailed Description
A common practice used to control autonomic responses during surgery is to administer beta-blockers intraoperatively. This practice has been shown to effectively blunt autonomic responses to intraoper...
Eligibility Criteria
Inclusion
- Patients scheduled to undergo single-level or double-level laminectomy under general anesthesia
- Willingness and ability to sign an informed consent document
- No allergies to any of the anesthetic or analgesic medications being used for the study, as outlined in the study protocol
- Between 18-80 years of age
- American Society of Anesthesiologists (ASA) class I-III adults of either sex
Exclusion
- Patients who are ASA class IV or higher
- Patients with known allergy, hypersensitivity, or contraindication to the use of any of the medications being used for the study, as outlined in the study protocol
- Patients who are heavy chronic opioid users, defined for the purposes of this study as any patient who is taking the equivalent of 10mg of oral morphine per day or greater
- Pregnant or lactating women
- Patients with a history of drug or alcohol abuse within the past 3 months
- Patients with any other medical conditions or who are using any medications which may interfere with the conduct of the study (including patients taking clonidine, patients with EKG conduction defects and who are taking calcium channel blockers, patients with clinically significant congestive heart failure (CHF) or bronchospasm, or patients with second- or third-degree heart block, symptomatic sinus bradyarrhythmia, or nonsinus rhythm on preoperative EKG.)
Key Trial Info
Start Date :
June 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2015
Estimated Enrollment :
33 Patients enrolled
Trial Details
Trial ID
NCT01179113
Start Date
June 1 2011
End Date
May 1 2015
Last Update
November 2 2016
Active Locations (1)
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1
Cedars Sinai Medical Center
Los Angeles, California, United States, 90048