Status:
TERMINATED
Regional Anesthesia and Lung Cancer Recurrence
Lead Sponsor:
The Cleveland Clinic
Conditions:
Lung Cancer
Eligibility:
All Genders
18-85 years
Phase:
NA
Brief Summary
Test the effect of combined regiona/general anesthesia on lung cancer recurrence compared to general anesthesia alone.
Detailed Description
Surgery is the primary treatment of lung cancer, but surgery releases tumor cells into the systemic circulation. Whether this minimal residual disease results in clinical metastases is a function of h...
Eligibility Criteria
Inclusion
- Primary non-small cell lung cancer (stage 1-3) as determined according to the IASLC Lung Cancer Staging Project;
- Scheduled for potentially curative tumor resection;
- Written informed consent, including willingness to be randomized to epidural anesthesia/analgesia plus general anesthesia or to general anesthesia and postoperative opioid analgesia.
Exclusion
- Any contraindication to epidural anesthesia, (including coagulopathy, abnormal anatomy).
- Any contraindication to midazolam, propofol, sevoflurane, fentanyl, morphine, or hydromorphone.
- Age \< 18 or \> 85 years old.
- Other cancer not believed by the attending surgeon to be in long-term remission.
Key Trial Info
Start Date :
August 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2015
Estimated Enrollment :
67 Patients enrolled
Trial Details
Trial ID
NCT01179308
Start Date
August 1 2010
End Date
August 1 2015
Last Update
September 15 2016
Active Locations (2)
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1
Cleveland Clinic
Cleveland, Ohio, United States, 44195
2
Shanghai Chest Hospital
Shanghai, China